J Bone Jt Infect 2019; 4(4):198-202. doi:10.7150/jbji.35428

Research Paper

Prosthetic-joint Infections: Mortality Over The Last 10 Years

Arnaud Fischbacher, Olivier Borens

Centre hospitalier universitaire vaudois (CHUV), Service d'orthopédie et de traumatologie, Rue du Bugnon 46, 1011 Lausanne, Switzerland.

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Fischbacher A, Borens O. Prosthetic-joint Infections: Mortality Over The Last 10 Years. J Bone Jt Infect 2019; 4(4):198-202. doi:10.7150/jbji.35428. Available from http://www.jbji.net/v04p0198.htm

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Background: There is a constant increase of joint arthroplasties to improve the quality of life of an ever-aging population. Although prosthetic-joint infections are rare, with an incidence of 1-2%, they represent a serious complication in terms of morbidity and mortality. Infection related mortality is known to be approaching 8% at one year. The aim of this retrospective study is to reassess the one and two-year mortality over the last ten years.

Methods: Patients treated for prosthetic joint infection at the University Hospital of Lausanne (Switzerland) between 2006 and 2016 were included. The one and two-year cumulative mortality depending on sex, age, type of prosthesis, infecting organism and type of surgical treatment were computed.

Results: 363 patients (60% hips, 40% knees) were identified with a median age of 70 years. The one-year cumulative mortality was 5.5% and it was 7.3% after two years. No difference was seen between hip and knee prostheses, but the mortality was higher in men than in women and increased with age. Furthermore, there was a significant difference depending of the germ with enterococci infections associated with a higher risk of death. Finally, patients treated with a one-stage or two-stage exchange had a lower mortality than those treated with debridement and retention.

Conclusion: The mortality is still high and differs according to sex, age, infecting organism and type of surgical treatment. There is a need of studies to improve the management of patients at risk of increased mortality.

Keywords: prosthetic-joint infection, mortality