J Bone Jt Infect 2018; 3(4):207-211. doi:10.7150/jbji.27811

Research Paper

Daptomycin Plus Fosfomycin as Salvage Therapy in a Difficult-to-Treat Total Femoral Replacement Infection

Gonzalo Luengo1, Jaime Lora-Tamayo2✉, Diana Paredes2, Irene Muñoz-Gallego3, Antonio Díaz4, Emilio Delgado1

1. Department of Orthopaedic surgery and Traumatology, Hospital Universitario 12 de Octubre. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12). Madrid, Spain.
2. Department of Internal Medicine, Hospital Universitario 12 de Octubre. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12). Madrid, Spain.
3. Department of Microbiology, Hospital Universitario 12 de Octubre. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12). Madrid, Spain.
4. Department of Plastic Surgery, Hospital Universitario 12 de Octubre. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12). Madrid, Spain.

Abstract

The highly active anti-biofilm combination of daptomycin plus fosfomycin was successfully used in a difficult-to-treat infection of a total femoral replacement caused by multi-drug resistant Staphylococcus epidermidis in a 79-year-old woman. There was no need to remove the orthopedic hardware, and the patient is currently pain free and able to walk.

Keywords: prosthetic joint infection, biofilm, Staphylococcus, bone and joint infection

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How to cite this article:
Luengo G, Lora-Tamayo J, Paredes D, Muñoz-Gallego I, Díaz A, Delgado E. Daptomycin Plus Fosfomycin as Salvage Therapy in a Difficult-to-Treat Total Femoral Replacement Infection. J Bone Jt Infect 2018; 3(4):207-211. doi:10.7150/jbji.27811. Available from http://www.jbji.net/v03p0207.htm