J Bone Jt Infect 2018; 3(1):1-4. doi:10.7150/jbji.22459

Short Research Paper

Staphylococcus epidermidis isolates from nares and prosthetic joint infections are mupirocin susceptible

Lavin Salih1, Staffan Tevell1,2, Emeli Månsson1,3, Åsa Nilsdotter-Augustinsson4, Bengt Hellmark1, Bo Söderquist1✉

1. School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
2. Department of Infectious Diseases, Karlstad Hospital, Sweden
3. RegionVästmanland - Uppsala University, Centre for Clinical Research, Hospital of Västmanland, Västerås, Sweden
4. Division of Infectious Diseases, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, and Department of Infectious Diseases, County Council of Östergötland, Linköping, Sweden


The objective of the present study was to investigate the antibiotic susceptibility including mupirocin among Staphylococcus. epidermidis isolated from prosthetic joint infections (PJIs) (n=183) and nasal isolates (n=75) from patients intended to undergo prosthetic joint replacements. Susceptibility to mupirocin (used for eradication of nasal carriership of Staphylococcus aureus) was investigated by gradient test, and susceptibility to various other antimicrobial agents was investigated by disc diffusion test. All isolates, except three from PJIs and one from the nares, were fully susceptible to mupirocin. Multi-drug resistance (≥3 antibiotic classes) was found in 154/183 (84.2%) of the PJI isolates but only in 2/75 (2.7%) of the nares isolates, indicating that S. epidermidis causing PJIs do not originate from the nares.

Keywords: Staphylococcus epidermidis, Prosthetic joint infections, Mupirocin, Antibiotic susceptibility testing

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How to cite this article:
Salih L, Tevell S, Månsson E, Nilsdotter-Augustinsson Å, Hellmark B, Söderquist B. Staphylococcus epidermidis isolates from nares and prosthetic joint infections are mupirocin susceptible. J Bone Jt Infect 2018; 3(1):1-4. doi:10.7150/jbji.22459. Available from http://www.jbji.net/v03p0001.htm